Glucuronolactone is commonly used as an ingredient in energy drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use. Clin Cosmet Investig Dermatol. cl2 + kbr observation. Is Clostridium difficile Gram-positive or negative? Glucuronolactone comes from animal tissues. He teaches classes on topics which include exercise, weight loss, stress management, sleep, and healthy eating. However, the dose of B vitamins used in energy drinks may exceed recommended daily intakes. This largely depends on what type of product you're using and what other ingredients you're using. As mentioned previously, the effects of glucuronolactone in humans have otherwise only be evaluated using energy drinks. what does cash on hand mean in toast? 10. In rats with liver disease, D-glucuronolactone lowered liver inflammation (IL-6, NF-B) and tissue injury markers. And that makes it notably more gentler, with the potential for unsightly side effects such as redness and flaking greatly decreased. What is fructose? There are a few common ingredients found in the most popular energy drinks, and were going to break down for you what they are and how or if they work to boost your energy. Ebola, like many viruses, works in part by inhibiting interferona type of molecule that cells use to hinder further viral reproduction. For vitamin C, zinc, and copper, you should also be . Your body breaks down foods such as sucrose and starch into fructose and glucose during digestion. View abstract. Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Exfoliating can be tricky when you're battling acne. This soap-free cleanser is gentle enough to use twice daily (and it also foams nicely). Any adverse effects mentioned below are due to energy drink consumption as a whole; they may or may not be related to glucuronolactone. Energy drinks induce acute cardiovascular and metabolic changes pointing to potential risks for young adults: A randomized controlled trial. With 10% gluconolactone this, "helps to exfoliate the millions of dead skin cells we lose every day, but does so gently, while hydrating at the same time," says Gohara of one of her go-tos. Celsius energy drink is advertised as a clinically proven dietary supplement that boosts metabolism and elevates energy levels. However, you shouldnt interpret them as supportive of any health benefit. However, the benefits of supplementation lack clinical evidence. Men between the ages of 18 and 34 years consume the most energy drinks, and almost one-third of teens . At this time there is not enough scientific information to determine an appropriate range of doses for glucuronolactone. And what kind of benefits can we expect from this ingredient? It is a major constituent of bile and can be found in the large intestine, and accounts for up to 0.1% of total human body weight. It can be made by the body. of the Scheweiger Dermatology Group in New York City, and Mona Gohara, M.D., associate clinical professor of dermatology at Yale School of Medicine, weigh in on this under-the-radar ingredientand why it's worth not only knowing about, but incorporating into your skincare routine, too. But if it was made on an artificial method (which some companies claim) with no animal source, it could be considered halal. People with medical conditions should consult their physician before taking this supplement. [5] The U.S. Food and Drug Administration considers 400 milligrams (about 4 cups brewed coffee) a safe amount of caffeine for healthy adults to consume daily. Comment * document.getElementById("comment").setAttribute( "id", "aaa0ccbee883aab6082d78e3be7392dd" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Avoid this supplement if you are pregnant, nursing or under the age of 18. Caffeine is, however, not without risk. D-glucuronolactone is also present in animal connective tissues, certain plants and energy drinks. It is one of the most abundant amino acids in the muscle tissue, brain, and many other organs in the body. Identification of d-glucaric acid as a normal constituent of urine. Main Benefits: Improves skin texture and tone, hydrates, offers some antioxidant benefits. Jpn J Pharmacol. Glucuronolactone, a naturally occurring chemical in human connective tissue, is a major free-radical scavenger that the liver uses to detoxify the body of harmful wastes. Too much caffeine can have dangerous side effects. In supplement form, glucuronolactone is usually taken at 500 1,000 mg/day. Well, you can find Glucuronolactone in most energy drinks. Red Bull also contains glucuronolactone, a sugar derivative used to prolong shelf-life. In a study on human plasma, a product of glucuronolactone breakdown (D-glucaro 1,4-lactone) decreased damage to the blood proteins caused by free radicals. All rights reserved. Which major brands use taurine: Pretty much all of them notably Red Bull, Monster Energy, Rockstar Energy Drink and NOS Energy Drink. They either buy energy drinks that include DGL or dietary supplements. Jordan Kally is a certified strength and conditioning specialist and a registered yoga teacher. Metabolism of d-glucuronolactone in mammalian systems. Youll see Glucuronolactone on the labels of various energy-enhancement products. It is also very safe and has no known side effects when taken in reasonable doses. Chalerm Yoovidhya (51%)Dietrich Mateschitz (49%). It activates pathways that bind and flush drugs, pollutants, and toxins. But while AHAs and BHAs often steal the skincare spotlight, PHAs, gluconolactone in particular, most definitely deserve a place at the table. Cartilage's elasticity and tensile strength is derived from chondroitin sulfate proteoglycans binding covalently in the extracellular collagen matrix. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. In general, regulatory bodies arent assuring the quality, safety, and efficacy of supplements. Its an anti-platelet aggregative compound. Though the amount of Glucuronolactone in energy drinks may vary from brand to brand, there are around 600mg available in most beverages. Red Bull has 80 mg of caffeine in an 8.4-ounce can. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. It can be made by the body. Taking Red Bull can result in the release of the . The Mayo Clinic advises not drinking more than 400 mg of caffeine a day. In clinical studies, acute and chronic consumption of energy drinks had the following negative effects [26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39]: We can assume that a great deal of these effects could be due to high amounts of caffeine, sugars, and other components. Glucuronolactone is an essential component for detox. Note that each number in parentheses [1, 2, 3, etc.] In an average diet, glucuronolactone intake through food sources is estimated to be very low (1.2 mg/day) [42]. Foods that contain all nine essential amino acids are called complete proteins. When your blood glucose rises after you eat, the beta cells release insulin into your bloodstream. Although caffeine citrate acts faster than caffeine anhydrous, it has one major drawback 20mg of caffeine citrate provides only 10mg of active caffeine. People who consumed energy drinks containing DGL showed improvements in concentration, memory, alertness and reaction time (x). Glucuronolactone is a naturally-occurring substance and a lesser-known ingredient in energy drinks like Red Bull. The compound is composed of linear repeating units of D-glucuronic acid (DGA) and N-acetyl-D-galactosamine (GalNAc) with sulfate groups attached at the 4 or 6 carbon. A fan-favorite among derms, this contains a 12 percent PHA blend, combining gluconolactone and lactobionic acid. Biochem J. She covers all things skincare for Byrdie, from ingredients to acne advice. It is also found in foods and made in laboratories. Its not necessarily considered an active ingredient, but more of a supporting player, thanks to both its mild exfoliating and hydrating properties," she says. The results indicated that taurine can enhance the sexual response and mating ability in aged male rats by increasing the level of testosterone and NO, but the exact mechanism of which needs to be further investigated. Glucono-what? And this way, you can reduce the chances of a heart attack or stroke. Users and supplement manufacturers have established unofficial doses based on trial and error. Your email address will not be published. Also nice: It's non-comedogenic, so there's no need to stress about clogged pores, and fragrance-free. Sucrose is readily metabolized by your body and used for energy, although too much at a time spikes blood sugar levels and insulin release while promoting fat storage. To stay on the safe side, avoid glucuronolactone supplements as clinical information is lacking on its dosage and side effects. SelfDecode is a personalized health report service, Therefore, you can easily ingest Glucuronolactone supplements without causing any harm to your body. Glucuronolactone plays a role in detoxifying the body from cancer-promoting chemicals, hormones, and pollutants. It also reduced the levels of a cancer marker, alpha-fetoprotein [23]. Therefore, if youre suffering from joint health issues, DGL can be your best shot. It can be taken in powder or capsule form and should be started at low doses of about 100 milligrams per day. And even though it naturally occurs in our body, we can take it orally to improve our overall health. "So someone who may not be able to tolerate AHAs could likely use gluconolactone without experiencing any irritation," she adds. OTHER NAME(S): D-Glucurono-1,4-lactone, D-Glucurono-3,6-lactone. Skin: Nicotine constricts the blood vessels, which prevent nutrients from getting to the skin. Pregnant women and lactating mothers should consult medical experts before ingesting DGL. Glucuronolactone is added to many energy drinks as a detoxifying agent. So, it can undoubtedly work to enhance your physical performance. 2011;4(8):31-49. Supplementation with a glucuronolactone breakdown product (D-glucaro 1,4-lactone) inhibited breast tumor growth in rats [22]. Glucuronolactone is most often used for Energy & Fatigue. 1966;99(1):22-7. Its one of the most effective ingredients that improve the conditions of our bone joints. Unfortunately, the amount of L-carnitine found in most energy drinks is not high enough to have any real effect. And while gluconolactone does work synergistically with other acids and retinoids, Gohara recommends separating them if your skin is sensitive. Part of HuffPost Food & Drink. Those who incorporate exercises to increase cardiac health and trim fat into lean muscle will likely consider glucuronolactone a necessary addition to their athletic routine. By entering your email and clicking Sign Up, you're agreeing to let us send you customized marketing messages about us and our advertising partners. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. An 8.4-ounce can of Red Bull contains 80 mg of caffeine, and NOS Energy Drink reportedly used to contain 260 mg, but they lowered their caffeine by 100mg per can to around 160 mg. For comparisons sake, an 8-ounce Dunkin Donuts coffee contains around 100 mg of caffeine, and an 8-ounce Starbucks coffee will rank closer to 160 mg of caffeine. Glucuronolactone . Glucuronic acid is involved in detox and the breakdown of glucose, as part of a specific pathway crucial for creating fatty acids, amino acids, and DNA components (known as the Pentose Phosphate Pathway) [3]. Tips: Green, white and black teas do usually contain caffeine, so you may still want to keep your consumption moderate and don't drink it before bed. Animal and Cellular Research (Lacking Evidence), 1) Blood Clotting and Antioxidant Protection. That said, energy drinks contain numerous ingredients aside from glucuronolactone, including caffeine, taurine, glucose, and B-vitamins. View abstract. Youll face the side effects of Glucuronolactone when you have an overdose. Guarana is a plant that grows in the Amazon and produces berries that contain caffeine, even more so per serving than coffee. Hence, this article will be your ultimate guide if youre thinking about its supplementation. Niacin, in particular, can help break down carbohydrates, fats, lipid forms, and sugars, which lead to a healthy digestive cycle. But there's one thing you need to keep in mind. Otherwise, use it a few times per week. In physiological trials, glucuronolactone has been shown to inhibit the synthesis of toxic by-products of intensive exercise as well as other negative effects causing fatigue (Tamura et al, 1968). Digestive tract functioning can improve with sufficient vitamin consumption. Not only does glucuronolactone help to improve physical performance, but it also increases mood and mental performance. Additional Fiber Benefits. Well, one of the most vital components responsible for that is Glucuronolactone. While it is safe, though, it is best to consult with your doctor before adding DGL to your regimen. Glucuronolactone is a molecule commonly found as a component of energy drink formulations with surprisingly minimal research on it, given its societal usage. Glucuronolactone is commonly used as an ingredient in "energy" drinks to . Not only does glucuronolactone help to improve physical performance, but it also increases mood and mental performance. Glucuronolactone is also important in the production of Vitamin C, thereby making it an essential component for improved immunity and overall body resistance. Which major brands use L-carnitine: Monster Energy, Rockstar Energy Drink and NOS Energy Drink. DGL have been heavily studied in the numerous products that contain it particularly sports and energy drinks (x). D-glucuronolactone provides numerous benefits to our bodies including sharper mental focus, enhanced physical performance and a more positive outlook. You can get tons of benefits from Glucuronolactone; theres no doubt about that. Large bottles (16-24 oz) contain even more caffeine. Part-time sports journalist covering the Vegas Golden Knights. Sucrose. Increase in blood cholesterol levels. Moisture loss is one of the causes of aged-looking skin. 11 - Improves digestion. Side effects, if any, tend to be mild and may include nausea, stomach pain, tiredness, headache, and dizziness. Accessed June 24, 2020. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Looking for medically accurate, up-to-date, evidence-based educational programming for health care providers and materials for patients on all reproductive health topics, including abortion, contraception, HPV, menopause, menstruation, pregnancy, sexuality? Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. Glucuronolactone is a normal product of glucose breakdown in the liver. Your email address will not be published. After ingesting it, well be able to focus on tedious things without trouble. But when we miss multiple workout sessions, well fail to achieve the physique of our dream. Keep in mind that the safety profile of glucuronolactone is relatively unknown, given the lack of well-designed clinical studies. Glucuronolactone is a chemical. Find out if the popular claims about its benefits are valid and learn the potential dangers. This amount is proven to be effective if taken 10 minutes before the workout sessions. As a result, this ingredient has the ability to prevent the platelets from sticking together. This is no surprise, because DGL contributes to the structure of our tendons, ligaments and cartilage. This compound is found and produced in our connective tissues, such as ligaments and cartilage. When combined with other ingredients such as taurine and caffeine in energy drinks, DGL enhances an individuals momentum to carry out daily tasks (x,x). Overview. Examples of energy drinks include Monster, Red Bull, and Rockstar. Click here to purchase d-glucuronolactone powder now. It plays nice with most other ingredients, although you may want to be cautious about over-exfoliation when its used in tandem with other acids or exfoliants such as retinoids. Kornhauser A, Coelho SG, Hearing VJ. Though as with any topical acid, you want to be extra cautious if you have a condition where the skin is compromised, such as rosacea or atopic dermatitis, she adds. Glucuronolactone converts to glucuronic acid in the body. These structures support our bones. Glucuronolactone is a normal product of glucose breakdown in the liver. However, clinical research about the specific effects of this compound is scant. If you want to take it as a pre-workout supplement, you can ingest 350mg of DGL. Although sugars can cause a quick increase in energy levels, the effects are short-lived. Pre workout side effects. Conversion of d-glucuronolactone into d-glucaric acid by tissue preparations. Vitamin B6. Antivirals. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. View the full answer. Vitamin B6 is found in meats, whole grain products, vegetables . And it also strengthens bones, another fantastic benefit we can enjoy. Glucuronolactone can be combined with other active ingredients, such as caffeine, to improve endurance. It is also found in foods and made in laboratories. Additionally, if you're a minor or pregnant, it is important to consider that your body may not process caffeine as well as an adult, which is why moderation is key. The European Food Safety Authority (EFSA) has adopted a scientific opinion on two ingredients commonly used in so-called energy drinks. Taurine occurs naturally in the human brain. We believe that the most accurate information is found directly in the scientific source. Glucuronic acid plays a key role in a detox pathway known as glucuronidation. Basrai M, Schweinlin A, Menzel J, et al. A proper diet is required for that purpose, and you can only use this supplement as a boost. Most clinical studies used energy drinks, which contain many additional ingredients, some of which can have detrimental health effects. Have you ever thought about why you feel so lively after an energy drink? In addition, DGL helps people to feel better about their overall well-being . But it would be better to start with a minimal dose and increase it gradually, depending on how you feel. Next to multivitamins, energy drinks are the most popular dietary supplement consumed by American teens and young adults. In addition, DGL supports muscle development, which is good news for bodybuilders. B vitamins are commonly called upon for energy boosting, but the problem is that unless you have a B vitamin deficiency, they dont really do much. Well, you can find Glucuronolactone in most energy drinks. According to The Merck Index, glucuronolactone is used as a detoxicant. Pre workout side effects can vary based on the ingredients present. If youre having a rough day, you can take this to inspire your body to go the extra mile. While taurine is thought to be vital in some body development, there is no actual evidence that taurine provides energy at all. Energy drinks are widely promoted as products that increase energy and enhance mental alertness and physical performance. As a supplement, its available in the powder/capsule form. The difference? Like most popular soft drinks, Red Bull is largely sugar water. A 16 ounce can of Red Bull contains 220 calories. This naturally-occurring amino acid made by the liver and kidneys does affect energy levels, which is why so many energy drink companies call upon it. However, pregnant women should limit their caffeine intake to . Glucuronolactone is also metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Evaluation of the Neurobehavioural Toxic Effects of Taurine, Glucuronolactone, and Gluconolactone Used in Energy Drinks in Young Rats. Turkish Journal of Pharmaceutical Sciences 17, no. Users taking glucuronolactone supplements generally report an increase in physical performance, stamina, improved mood, and reduced mental fatigue. When youre feeling confused, stressed, or anxious, Glucuronolactone will elevate your mood so you can chill. Glucuronolactone might protect the liver by enhancing the glucuronidation detoxification pathway. Yes, its a gluten-free ingredient, safe for patients with gluten-related disorders. You can use Glucuronolactone powder for your daily supplementation. People with anxiety and heart conditions should not consume energy drinks. It can be made by the body. Since DGL is so common in energy drinks, any side effects reported may relate to the cocktail of ingredients included and not specifically to DGL. Glucuronolactone is actually a naturally-occurring chemical produced by the body (and found in plant gums). However, an all-natural dietary supplement will yield the same benefits without risking adverse effects of additional ingredients that are present in energy drinks. Glucuronolactone is a popular ingredient in energy drinks. Energy drinks have 80-400 mg of caffeine, depending on the size of the drink and mix of ingredients. Sometimes called fruit sugar, fructose is found in fruit, some vegetables, honey, and other plants. Taurine, or 2-aminoethanesulfonic acid, is an organic compound that is widely distributed in animal tissues. Jonathan Ritter, PharmD, PhD (Pharmacology), Might have heart- and liver-protecting benefits, Combined with potentially harmful ingredients into energy drinks, Animal studies only examined its breakdown products, Cancers: brain, colon, pancreatic, breast and prostate, Negative cardiovascular impact: increase in blood pressure and, Metabolic effects: obesity, increased risk of developing type 2 diabetes. So, it can undoubtedly work to enhance your physical performance. Withdrawal symptoms begin 12 to 24 hours after you last had any and can linger for up to 7 days. school closings today syracuse ny; best schools in zimbabwe; danganronpa cocktails. Multiple studies have debunked the so-called sugar high. The appropriate dose of glucuronolactone depends on several factors such as the user's age, health, and several other conditions. Meet Lactobionic Acid: AHA's Gentler Sister Exfoliator, The 13 Best Chemical Exfoliators for Smooth, Soft, and Radiant Skin, 18 Skincare Products With AHA/BHA For Smoother Skin, Derms Say Glycolic Acid Is the Ultimate Anti-Aging ExfoliatorHere's Why, 21 Best Face Exfoliators to Use Now for Soft, Glowing Skin, Derms Say Lactic Acid Can Significantly Reduce Breakouts and Fine Lines, 6 Less Expensive Biologique Recherche Lotion P50 Dupes, 10 Foolproof Ways to Unclog Pores, According to Skincare Experts, Meet Mandelic Acid, an AHA Suited for Sensitive Skin, Here's Why Dermatologists Say Alpha Hydroxy Acids Are the Best Exfoliant, The 9 Best Exfoliating Face Washes of 2023, The 13 Best Exfoliators That Are Gentle Enough for Sensitive Skin, The 8 Best Treatments for Keratosis Pilaris of 2023. Which major brands use B vitamins: Red Bull, Monster Energy and Rockstar Energy Drink. It is sometimes used in energy drinks [2] [3] . It comes in several different flavors and is free of sugar and preservatives. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. An 8.4-ounce can of Red Bull contains 80 mg of caffeine, and NOS Energy Drink reportedly used to contain 260 mg, but they lowered their caffeine by 100mg per can to around 160 mg. For comparison's sake, an 8-ounce Dunkin' Donuts coffee contains around 100 mg of caffeine, and an 8-ounce Starbucks coffee will rank closer to 160 mg of caffeine. Its completely legal, and theres no age restriction. Youll get all the caffeine, and you get to decide how much sugar goes into it. Antibacterial benzoyl peroxide is meant to zap zits, while gluconolactone is meant to gently exfoliate without causing irritation. Read our, Hydrating Serum, Antioxidant Skin Booster, Restore Ultra Moisturizing Face Cream 10 PHA. They discovered for example that during long-term and intensive exercise all sorts of toxic waste products start to circulate through the body, which in ex-vivo studies had shown that . Your body requires a constant supply of energy. The metabolic effects of inositol may not be appropriate for everyone. In other words, use them on alternate days, or use a gluconolactone product in the morning and a different acid and/or retinoid at bedtime. Because of its many benefits, DGL is a powerful supplement that enhances physical and mental functions of our bodies. L-carnitine, and carnitine in general, is a key component in creating energy for the cells. Anyone can find value in this supplement because it provides the one thing that each one of us needs to make it through the day energy. But what is the correct procedure to take it? Jordan is a gym owner in New York, where he holds personal training/health coaching sessions. Glucuronolactone is commonly used as an ingredient in energy drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use. Red Bull contains several B vitamins. What should you avoid using gluconolactone with? Taurine. Like the others, it's choice for improving skin tone and texture, dissolving the dead cells that leave your complexion rough and lackluster. About 25% of glucuronolactone is quickly converted to it. Consult your physician before consuming them, especially if you take prescription medication or have heart or mental health problems. It is also found in foods and made in laboratories. Other common side effects from different ingredients may include digestive issues, headaches, bloating, and water retention. It is also found in foods and made in laboratories. It binds to chemical and environmental toxins, pharmaceutical drugs, and cancer-causing molecules. Doctors may recommend taurine supplements for congestive heart failure, angina, cystic fibrosis and other respiratory and heart conditions. However, energy drinks contain a number of other ingredients that may impose adverse effects on our bodies (x). D-glucuronolactone provides support for both. Once again, Red Bull contains caffeine and other active ingredients that likely contributed to these results. 2016;4(12 Suppl Anatomy and Safety in Cosmetic Medicine: Cosmetic Bootcamp):e1152. In an observational study of 10 graduate students, drinking Red Bull led to faster motor reaction time, improved attention and decision making when compared to the control group [17]. Case in point: This is meant to be used daily to help brighten dull skin, fade dark spots, and even combat blackheads and clogged pores. Glucuronolactone is a naturally occurring metabolite formed from glucose in the liver and is found in a small number of foods of which wine is the richest source (up to 20 mg/L). All connective tissues contain it, as well as many plant gums. Glucuronolactone is derived from gluconic acid. Side effects may include nervousness/anxiety, shaking, racing heart and confusion. . L-Carnatine is a nutrient in your body formed by amino acids lysine and methionine with the assistance of vitamin C. It is involved in energy . The energy drink industry pulls in roughly 9 billion dollars annually, so its obvious that many of us turn to these sugary drinks when we need a jolt of energy. Its this high caffeine content that makes this tropical berry a natural addition in energy drinks. In 2011 alone, energy drinks caused more than 20,000 hospital visits and have led to at least 34 deaths to date. There are reports of patients having adverse effects from drinking taurine-containing energy drinks. It acts as a protectant for our blood vessels by regulating platelet functions. Sucrose is a type of carbohydrate called a disaccharide, which is a variety of sugar. Taurine is an herbal supplement that can be used in the treatment for congestive heart failure, high blood pressure, high cholesterol, cystic fibrosis, and to prevent the buildup of plaque in the arteries throughout the body. Information is shared for educational purposes only. These resources are produced by Dr. Rachel Scherr and her research staff. The drugs can ease symptoms and shorten the length of a viral infection. Marsh CA. Caffeine is a stimulant, which means it increases activity in your brain and nervous system. However, mild side effects have been reported with doses of 12 grams per day or higher. In a rat study, high doses of glucuronolactone enhanced physical performance and increased stamina given shortly before swimming exercises [14]. Spironolactone ( Aldactone) is one of the most common treatments for hormonal acne, as well as alopecia (hair loss), oily skin, and hirsutism (hair growth on face, chest, or back in women). G Fuel is advertised as a clean and healthy alternative to sugar-loaded energy drinks. Taurine occurs naturally in . In fact, its just the opposite, as the ingredient is added to popular energy drinks as a nervous system depressant and just has a stimulating effect on the brain. No clinical evidence supports the use of glucuronolactone for any of the conditions listed in this section. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. View abstract. You cannot solely depend on Glucuronolactone to energize your body.